MLB Schedule Today: How to Watch Every Game on May 16, 2025

Here's your comprehensive guide to today's Major League Baseball action, taking place on Friday, May 16, 2025. Get ready for a full slate of interleague rivalries and divisional matchups!

The day kicks off with a Windy City showdown as the Chicago White Sox visit their crosstown rivals, the Chicago Cubs, with first pitch slated for 2:20 p.m. Eastern time.

As evening approaches, the baseball excitement continues with a host of games. Ohio baseball fans can tune in as the Cleveland Guardians travel to face the Cincinnati Reds at 6:40 p.m. Eastern. Simultaneously, the Philadelphia Phillies will host the Pittsburgh Pirates, and the Washington Nationals head north to Baltimore to play the Orioles at 6:45 p.m. and 7:05 p.m. Eastern respectively.

Adding to the New York baseball fervor, the Mets will battle the Yankees in a Subway Series matchup at 7:05 p.m. Eastern time. Across the border, the Toronto Blue Jays will host the Detroit Tigers at 7:07 p.m. Eastern. Down south, the Atlanta Braves visit Fenway Park to take on the Boston Red Sox, while the Tampa Bay Rays will play against the Miami Marlins at 7:10 p.m. Eastern in their own Florida rivalry game.

As the sun begins to set further west, the St. Louis Cardinals will travel to Kansas City to face the Royals at 7:40 p.m. Eastern. Two games will be available on Apple TV tonight, the Houston Astros will be facing the Texas Rangers at 8:05 p.m. Eastern.

The evening continues with the Minnesota Twins heading to Milwaukee to play the Brewers at 8:10 p.m. Eastern time.

Later into the night, west coast games begin. The Colorado Rockies will be visiting the Arizona Diamondbacks, while the Seattle Mariners travel to San Diego to play the Padres, with both games starting at 9:40 p.m. Eastern. Apple TV has you covered for the Mariners vs Padres game!

Capping off the night, the Los Angeles Angels will face their city rivals, the Los Angeles Dodgers, at 10:10 p.m. Eastern, followed by the Oakland Athletics visiting the San Francisco Giants at 10:15 p.m. Eastern.

Don't miss a single pitch! Several games will be broadcast on regional sports networks; check your local listings for channel information. You can also catch games all season long with a subscription to Fubo, which offers a free trial.